Research Snapshot: Study demonstrates protein infusion can restore bone marrow function and rejuvenate the hematopoietic system

A new paper published in Nature Communications, led by Jason Butler, Ph.D., demonstrates that the Netrin-1 protein is a key regulator of cells in the bone marrow niche during homeostasis, regeneration and aging. The study is the first to show that infusing NTN1 into the body rejuvenates the BM niche and restores the regenerative capacity of aged hematopoietic stem cells.


National effort to improve patient outcomes to enhance cancer implementation science research

UF Health is among 42 health systems nationwide chosen by the Patient-Centered Outcomes Research Institute to carry out pioneering initiatives to accelerate the implementation of practice-changing research results in clinical care to improve patient outcomes. UF Health’s new involvement in the PCORI Health Systems Implementation Initiative will provide opportunities to enhance ongoing cancer population and implementation science research at the Cancer Center.


Sylvester hosts 2023 FACCA Retreat

The UF Health Cancer Center joined Moffitt Cancer Center and Sylvester Comprehensive Cancer Center at the 2023 Florida Academic Cancer Center Alliance (FACCA) Retreat held March 27-28 in Miami. The collaboration helps to ensure quality research, as the centers that make up FACCA adhere to the ideals set forward federally through the NCI, said Jonathan D. Licht, M.D.


Research Snapshot: Study reveals targeting a specific protein with a small molecule inhibitor can improve outcomes

A new study published in Clinical Cancer Research revealed that inhibition of the IRAK-4 protein with a small molecule inhibitor called CA-4948 can downregulate the expression of transcription factors related to cancer, even inside the blood-brain barrier. This discovery could have significant implications for treating certain types of cancer like primary central nervous system lymphoma and melanoma brain metastases.


Project CONTINUITY connects community to care

The UF Health Cancer Center’s Project CONTINUITY helped community members learn about cancer prevention and access health services during a free health fair featuring 15 community partners on March 25 in Bo Diddley Plaza. In recent months, the Office of Community Outreach and Engagement has been growing its ranks to increase its impact in the community.


UF Nursing researchers coach cancer survivors for post-treatment care

UF College of Nursing Associate Dean for Academic Affairs Debra Lynch Kelly, Ph.D., RN, OCN, CNE, FAAN, and Chamings Professor and Assistant Dean for Research Development Angela Starkweather, Ph.D., ACNP-BC, FAANP, FAAN, recently launched a partnership with Pack Health, a health coaching platform with a focus on chronic conditions, to study how weekly digital coaching sessions can improve health outcomes for individuals who have completed their initial cancer treatment.

Headshots of Debra Lynch Kelly and Angela Starkweather

NCI-funded project to study role of gut microbiome in prostate cancer

Christian Jobin, Ph.D., the Gatorade Trust Professor of Medicine in the division of gastroenterology, hepatology & nutrition in the UF College of Medicine, and Raad Gharaibeh, Ph.D., a research assistant professor in the division, have received a two-year $364,143 R21 grant from the National Cancer Institute to study the role of the gut microbiome in prostate cancer.


Department of Health Outcomes and Biomedical Informatics builds collaborative, AI-enabled learning health system

Led by Chair Elizabeth Shenkman, Ph.D., the UF College of Medicine department of health outcomes and biomedical informatics has been building a learning health system with UF Health and the UF Clinical and Translational Science Institute for years. Thanks to successful team science and UF’s artificial intelligence initiative, progress has developed rapidly, with promising impacts for students, scientists, practitioners and patients across the university, state and country.


Ramzi Salloum, Ph.D., selected to lead NCI action group

Ramzi Salloum, Ph.D., was selected to chair the Learning Healthcare Systems as Natural Laboratories action group. The group focuses on facilitating implementation research that advances the study and understanding of learning healthcare systems as natural laboratories for improving healthcare quality, equity and patient outcomes.