MAY 2025 PUBLICATIONS » Connection Newsletter » UF Health Cancer Center

Cancer Control AND Population Sciences

Cancer Targeting AND Therapeutics

Immuno-Oncology AND Microbiome

Mechanisms of Oncogenesis

Cancer Control and Population Sciences

Yaghjyan L, Tamimi RM, Baker GM, Heng YJ. Associations of stem cell markers with lobular involution in benign breast tissue. Cancer Epidemiol Biomarkers Prev. 2025 May 22. doi: 10.1158/1055-9965.EPI-25-0097. Online ahead of print. PubMed PMID: 40402075.

Lynch EJ, Faro SJE, Lindstrom AM, Sethi NA, Wang WY, Seligson ND. Revumenib for Relapsed or Refractory Acute Leukemia With a KMT2A Translocation. Ann Pharmacother. 2025 May 28:10600280251341279. doi: 10.1177/10600280251341279. Online ahead of print. PubMed PMID: 40437770.

Das A, Rodriguez Garcia GP, Rubio EC, Acosta GJ, Bylund CL, Brito JP, Ospina NS. Unmet Care Needs of Adult Survivors of Thyroid Cancer: A Systematic Review. JAMA Otolaryngol Head Neck Surg. 2025 May 22. doi: 10.1001/jamaoto.2025.0855. Online ahead of print. PubMed PMID: 40402541.

LeLaurin JH, Pluta K, Norton WE, Salloum RG, Singh Ospina N. Time to de-implementation of low-value cancer screening practices: a narrative review. BMJ Qual Saf. 2025 May 20:bmjqs-2025-018558. doi: 10.1136/bmjqs-2025-018558. Online ahead of print. PubMed PMID: 40393787.

Samami E, Starkweather A, Kelly DL, Lyon D. The Impact of Health-Promoting Lifestyle Behaviors on Gut Microbiota in Survivors of Hematological Cancer: A Scoping Review. Cancer Rep (Hoboken). 2025 May;8(5):e70224. doi: 10.1002/cnr2.70224. PubMed PMID: 40364600; PubMed Central PMCID: PMC12075932.

Chen Z, Zhang M, Ahmed MM, Guo Y, George TJ, Bian J, Wu Y. Narrative Feature or Structured Feature? A Study of Large Language Models to Identify Cancer Patients at Risk of Heart Failure. AMIA Annu Symp Proc. 2025 May 22;2024:242-251. eCollection 2024. PubMed PMID: 40417538; PubMed Central PMCID: PMC12099403.

Smither WW, Wang Y, Choi C, Dawson RJ, Wei Y, Dewji SA, Hooper D, Bolch WE. Development of a military-specific mesh-type computational phantom library and its application to internal dosimetry and in-field radiological triage screening. J Radiol Prot. 2025 May 30. doi: 10.1088/1361-6498/added1. Online ahead of print. PubMed PMID: 40446812.

Lavoie HA, Mejia D, Jake-Schoffman DE. Exploring fitness influencer content preferences among female college students in the southeastern United States. J Am Coll Health. 2025 May 20:1-13. doi: 10.1080/07448481.2025.2501007. Online ahead of print. PubMed PMID: 40393002.

Schuch LF, Kirschnick LB, Wagner VP, Velho VR, Llantada GS, Martins MAT, Marques MM, Pinheiro ALB, Santos JND, Santos-Silva AR, Migliorati CA, Martins MD. Shedding light on Brazil’s contribution to photobiomodulation research in oral medicine: a bibliometric study. Braz Oral Res. 2025 May 12;39:e052. doi: 10.1590/1807-3107bor-2025.vol39.052. eCollection 2025. PubMed PMID: 40367021; PubMed Central PMCID: PMC12074078.

Soupir A, Ospina OE, Hampton O, Churchman M, Radmacher M, Hedges D, McKean D, Agius P, Zeeshan S, Seligson ND, Pollock R, Liebner D, Chen JL, Tinoco G, Salhia B, McCarter M, Wilky BA, Miller BJ, Cavnar MJ, Groundland JS, Schneider BP, Riedlinger G, Edge SB, Moskaluk CA, Cardona K, Naqash AR, Gonzalez RJ, Mullinax JE, Joyce DM, Binitie O, Douglas Letson G, Naghavi AO, Druta M, Reed DR, Siegel EM, Teer JK, Fridley BL, Brohl AS. Genomic, transcriptomic, and immunogenomic landscape of over 1300 sarcomas of diverse histology subtypes. Nat Commun. 2025 May 6;16(1):4206. doi: 10.1038/s41467-025-58678-6. PubMed PMID: 40328759; PubMed Central PMCID: PMC12055966.

Khong J, Lee M, Warren C, Kim UB, Duarte S, Andreoni KA, Shrestha S, Johnson MW, Battula NR, McKimmy DM, Beduschi T, Lee JH, Li DM, Ho CM, Zarrinpar A. Tacrolimus dosing in liver transplant recipients using phenotypic personalized medicine: A phase 2 randomized clinical trial. Nat Commun. 2025 May 16;16(1):4558. doi: 10.1038/s41467-025-59739-6. PubMed PMID: 40379675; PubMed Central PMCID: PMC12084539.

Islam JY, Suneja G, Lin YC, McGee-Avila JK, Turner K, Alishahi Tabriz A, Vadaparampil ST, D’Souza G, Friedman MR, Guo Y, Camacho-Rivera M. Investigating structural inequities in area-level socioeconomic and health care access measures among people with HIV and cancer (2004-2020). Cancer. 2025 May 1;131(9):e35881. doi: 10.1002/cncr.35881. PubMed PMID: 40305646.

Azour L, Ohno Y, Biederer J, Hochhegger B, Bauman G, Hatabu H, Schiebler ML, Ackman JB. Lung MRI: Indications, Capabilities, and Techniques-AJR Expert Panel Narrative Review. AJR Am J Roentgenol. 2025 May 21. doi: 10.2214/AJR.25.32637. Online ahead of print. PubMed PMID: 40397559.

Expert Panel on GYN and OB Imaging; Venkatesan AM, Kilcoyne A, Akin EA, Chuang L, Hindman NM, Huang C, McCourt CK, Rauch GM, Sattari M, Schoenborn N, Schultz D, Sertic M, Small W Jr, Stein EB, Suarez-Weiss K, Kang SK. ACR Appropriateness Criteria(R) Ovarian Cancer Screening: 2024 Update. J Am Coll Radiol. 2025 May;22(5S):S359-S371. doi: 10.1016/j.jacr.2025.02.016. PubMed PMID: 40409887.

Expert Panel on Breast Imaging; Kuzmiak CM, Sharpe RE Jr, Lewin AA, Weinstein SP, Blinder V, Dibble EH, Dodelzon K, Dogan BE, Paulis LV, Plichta JK, Salkowski LR, Sattari M, Scheel JR, Slanetz PJ. ACR Appropriateness Criteria(R) Imaging of Ductal Carcinoma in Situ (DCIS). J Am Coll Radiol. 2025 May;22(5S):S274-S299. doi: 10.1016/j.jacr.2025.02.027. PubMed PMID: 40409882.

Li Z, King A, Souers RJ, Roberson JJ, Masood S, Alex D, Magers MJ, Hegde P, Tabbara SO. Breast Biomarker Cytology Practice in 2023: Results of a College of American Pathologists Survey. Arch Pathol Lab Med. 2025 May 7. doi: 10.5858/arpa.2025-0023-CP. Online ahead of print. PubMed PMID: 40331833.

Islam JY, Guo Y, McGee-Avila JK, Turner K, Tabriz AA, Lin YC, Vadaparampil ST, Coghill AE, Camacho-Rivera M, Suneja G. Inequities by race and ethnicity in cancer treatment receipt among people living with HIV and cancer in the U.S. (2004-2020). BMC Cancer. 2025 May 20;25(1):897. doi: 10.1186/s12885-025-14272-z. PubMed PMID: 40394520; PubMed Central PMCID: PMC12090492.

Kastrinos A, Salafia C, Gebert RR, Mroz EL, Fisher CL, Applebaum AJ. Getting Cancer Is “Just Bad Luck”: Exploring Bereaved Emerging and Young Adults’ Cancer Risk Uncertainty After Caring for a Parent With Advanced Cancer. Psychooncology. 2025 May;34(5):e70161. doi: 10.1002/pon.70161. PubMed PMID: 40325614.

Dai H, Huang Y, He X, Zhou T, Liu Y, Zhang X, Guo Y, Guo J, Bian J. Optimizing Strategy for Lung Cancer Screening: From Risk Prediction to Clinical Decision Support. JCO Clin Cancer Inform. 2025 May;9:e2400291. doi: 10.1200/CCI-24-00291. Epub 2025 May 7. PubMed PMID: 40334175; PubMed Central PMCID: PMC12061033.

Gbadamosi MO, Bhise N, Ghosh TM, Molchan EK, Streeks K, Puglise J, Ohaegbulam A, Makarem M, Olabige O, Yang C, Ricks-Santi L, Mitchell DA, Fridley BL, Lamba JK. A genome-wide association study using HapMap cell lines reveals modulators of cellular response to cyclophosphamide. Future Oncol. 2025 May 13:1-14. doi: 10.1080/14796694.2025.2501517. Online ahead of print. PubMed PMID: 40356407.

Flores MK, Janes JL, Islam M, Wan J, Liu J, Reams RR, Su LM, Yen K, Mehta HH, Reagan A, Howard LE, Wiggins E, Vidal AC, Freedland SJ, Cohen P. Mitochondrial DNA copy number assessment is a potent predictor for prostate cancer in White but not Black Individuals. Cancer Prev Res (Phila). 2025 May 13. doi: 10.1158/1940-6207.CAPR-24-0401. Online ahead of print. PubMed PMID: 40358482.

Foxx RK, Jake-Schoffman DE, Lavoie H, Mathews AE, Cheong J, Yurasek AM. Feasibility and Acceptability of a Novel Behavioral Economic Coaching Session to Address Physical Activity and TV Watching: An Open Pilot Trial. Int J Behav Med. 2025 May 29. doi: 10.1007/s12529-025-10368-9. Online ahead of print. PubMed PMID: 40442543.

Cancer Targeting and Therapeutics

Ducharme JB, Neyroud D, Schonk MM, Gutierrez-Monreal MA, Huo Z, Tucker HO, Esser KA, Judge SM, Judge AR. Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia. Cell Rep. 2025 May 10;44(5):115689. doi: 10.1016/j.celrep.2025.115689. Online ahead of print. PubMed PMID: 40349340.

Rushin A, Shaikh A, Hardin C, Deleyrolle LP, Merritt ME. Metabolic flux analysis of glioblastoma neural stem cells reveals distinctive metabolic phenotypes in ketogenic conditions. Sci Rep. 2025 May 28;15(1):18736. doi: 10.1038/s41598-025-02124-6. PubMed PMID: 40436928; PubMed Central PMCID: PMC12120007.

Gorwitz GL, DeRemer DL. Zolbetuximab-clzb: Targeting Claudin 18.2 in Advanced Gastric and Gastroesophageal Adenocarcinoma. Ann Pharmacother. 2025 May 27:10600280251342801. doi: 10.1177/10600280251342801. Online ahead of print. PubMed PMID: 40426305.

Indelicato DJ, Callan AK, Ahmed SK, Krailo M, DelRocco N, Buxton AB, Binitie OT, Christ AB, Kessell S, Chuba PJ, Nadel HR, Pawel BR, Gorlick R, Reed DR, DuBois SG, Janeway KA, Leavey P, Mascarenhas L, Laack NN. Preoperative Radiotherapy in Patients With Localized Ewing Sarcoma Enrolled on AEWS1031: A Report From the Children’s Oncology Group. Pediatr Blood Cancer. 2025 May 25:e31820. doi: 10.1002/pbc.31820. Online ahead of print. PubMed PMID: 40415235.

Nelson S, Gaza J, Ajayebi S, Masse R, Pho R, Scutero C, Martinusen S, Long L, Menezes A, Perez A, Denard C. PERRC: Protease Engineering with Reactant Residence Time Control. ACS Synth Biol. 2025 May 19. doi: 10.1021/acssynbio.5c00154. Online ahead of print. PubMed PMID: 40388903.

Clarke HA, Ma X, Shedlock CJ, Medina T, Hawkinson TR, Wu L, Ribas RA, Keohane S, Ravi S, Bizon JL, Burke SN, Abisambra JF, Merritt ME, Prentice BM, Vander Kooi CW, Gentry MS, Chen L, Sun RC. Spatial mapping of the brain metabolome lipidome and glycome. Nat Commun. 2025 May 12;16(1):4373. doi: 10.1038/s41467-025-59487-7. PubMed PMID: 40355410; PubMed Central PMCID: PMC12069719.

Dulloo ZM, Ghiviriga I, Law ME, Verma SK, Sharma A, Law BK, Castellano RK. Beta-cyclodextrin formulation of a disulfide-bond disrupting agent for improved systemic exposure. RSC Med Chem. 2025 May 21. doi: 10.1039/d5md00334b. Online ahead of print. PubMed PMID: 40453176; PubMed Central PMCID: PMC12124217.

Rosales RDR, Kanumuambidi JT, Venkatesh A, Al-Toubat M, Murray N, Balaji KC. Safety and efficacy of palliative transurethral resection of the prostate for lower urinary tract obstruction in patients with metastatic prostate cancer: a meta-analysis. World J Urol. 2025 May 22;43(1):320. doi: 10.1007/s00345-025-05664-8. PubMed PMID: 40402299.

Siemann DW, Malorzo W. Transdisciplinary team-based cancer research: a model for training the next generation of cancer researchers. Int J Radiat Biol. 2025 May 6:1-7. doi: 10.1080/09553002.2025.2494546. Online ahead of print. PubMed PMID: 40326798.

Mahadik JD, Middleton CE, Saulino D, Feely M, Chua T, Hong A, Nassour I, Assarzadegan N. Revisiting the Role of Epstein-Barr Virus (EBV) in Gastric Cancer: A Case Study of EBV in Normal, Dysplastic, and Malignant Gastric Epithelium. Int J Surg Pathol. 2025 May 30:10668969251343218. doi: 10.1177/10668969251343218. Online ahead of print. PubMed PMID: 40448325.

Lin SJ, Guo QJ, Liu Q, Ng WT, Ahn YC, AlHussain H, Chan AW, Chow J, Chua M, Corry J, Han F, Gregoire V, Harrington KJ, Hu CS, Jensen K, Langendijk JA, Le QT, Lee NY, Lee V, Lin JC, Ma J, Mendenhall WM, O’Sullivan B, Ozyar E, Rosenthal DI, Tao YG, Wang RS, Wee J, Xu ZY, Yi JL, Yom SS, Fan DM, Mai HQ, Pan JJ, Lee AWM. International Consensus Guideline on Delineation of the Clinical Target Volumes (CTV) at Different Dose Levels for Nasopharyngeal Carcinoma (2024 Version). Int J Radiat Oncol Biol Phys. 2025 May 24:S0360-3016(25)00487-0. doi: 10.1016/j.ijrobp.2025.05.019. Online ahead of print. PubMed PMID: 40419028.

Harris AK, Nelson AT, Watson D, Mallinger PHR, Messinger YH, Frazier AL, Stering A, Snyder SL, Levy CF, Kamihara J, Herzog CE, Lagmay J, Foresto S, Chen KS, Devins KM, Young RH, Hill DA, Dehner LP, Tadavarthy AK, Stall JN, Billmire DF, Schneider DT, Schultz KAP. Ovarian juvenile granulosa cell tumor: A report from the International Ovarian and Testicular Stromal Tumor and International Pleuropulmonary Blastoma/DICER1 Registries. Cancer. 2025 May 1;131(9):e35862. doi: 10.1002/cncr.35862. PubMed PMID: 40267023.

Krisch JM, Ermoian RP, Indelicato DJ, Lee JY, Perentesis JP, Perkins SM, Laack NN 2nd, Chang JH, MacEwan IJ, Wolden SL, Wang D, Yock TI, Aridgides PD. Outcomes following radiation therapy for embryonal tumor with multilayered rosettes (ETMR): results from the Pediatric Proton/Photon Consortium Registry (PPCR). J Neurooncol. 2025 May 13. doi: 10.1007/s11060-025-05065-2. Online ahead of print. PubMed PMID: 40358803.

Chen J, Trindl CA, Ye H, Huang D, Ooi A, Garcia JGN, Chapman E, Zhang DD. CYP4F11, an NRF2 Target Gene, Promotes Hepatocellular Carcinoma Cell Growth. Mol Carcinog. 2025 May 6. doi: 10.1002/mc.23925. Online ahead of print. PubMed PMID: 40329467.

Alperstein W, Lee JJ, Chellapandian D, Booth N, Galvez-Silva J, Joyce M, Milner J, Castillo P, Kashif R, Dalal M, Ligon J, Crawford D, Alicea Marrero MM, Peters J, Horn B, Dela Ziga E. Evolution of the Florida Pediatric Bone Marrow Transplant and Cell Therapy Consortium (FPBCC): A Statewide Initiative Toward Improving Transplant Outcomes. Pediatr Transplant. 2025 May;29(3):e70059. doi: 10.1111/petr.70059. PubMed PMID: 40045826; PubMed Central PMCID: PMC11883450.

Immuno-Oncology and Microbiome

Elliott L, Foster T, Castillo P, Mendez-Gomez H, Sayour EJ. Therapeutic mRNA vaccine applications in oncology. Mol Ther. 2025 May 6:S1525-0016(25)00362-4. doi: 10.1016/j.ymthe.2025.04.044. Online ahead of print. PubMed PMID: 40336197.

Green WD, Gomez A, Plotkin AL, Pratt BM, Merritt EF, Mullins GN, Kren NP, Modliszewski JL, Zhabotynsky V, Woodcock MG, Green JM, Cannon G, Pipkin ME, Dotti G, Thaxton JE, Pylayeva-Gupta Y, Baldwin AS, Morris JP 4th, Stanley N, Milner JJ. Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment. Immunity. 2025 May 22:S1074-7613(25)00193-1. doi: 10.1016/j.immuni.2025.04.030. Online ahead of print. PubMed PMID: 40425012.

Pham AT, Virk S, Oliveira AC, Alves MD, Fu C, Zhang Y, Alvarez-Castanon J, Lee BB, Lee KL, Mashina R, Ray KE, Donabedian P, Ebrahimi E, Patel H, Patel R, Lewis D, Huo Z, Karmouty-Quintana H, Chen L, Jin L, Bryant AJ. Opposing role for myeloid and smooth muscle cell STING in pulmonary hypertension. JCI Insight. 2025 May 22:e184792. doi: 10.1172/jci.insight.184792. Online ahead of print. PubMed PMID: 40402605.

Mechanisms of Oncogenesis

Xu H, Koganti S, Li C, McIntosh MT, Bhaduri-McIntosh S. STAT3, MYC, and EBNA1 cooperate through a ZC3H18 transcriptional network to regulate survival and proliferation of EBV-positive lymphomas. PLoS Pathog. 2025 May 12;21(5):e1013166. doi: 10.1371/journal.ppat.1013166. eCollection 2025 May. PubMed PMID: 40354417; PubMed Central PMCID: PMC12091888.

Mann MD, Wang M, Ferreon JC, Tsoi PS, Suess MP, Jain A, Malovannaya A, Alvarez RV, Pascal BD, Kumar R, Edwards DP, Griffin PR. Structural proteomics defines a sequential priming mechanism for the progesterone receptor. Nat Commun. 2025 May 12;16(1):4403. doi: 10.1038/s41467-025-59458-y. PubMed PMID: 40355435; PubMed Central PMCID: PMC12069617.

Paulsen K, Chan R, Gay L, Ma Z. KSHV miRNAs target STING to evade innate immunity and facilitate KSHV lytic reactivation from latency. Cell Rep. 2025 May 24;44(6):115741. doi: 10.1016/j.celrep.2025.115741. Online ahead of print. PubMed PMID: 40413741.

Shen Z, Yang X, Seabra G, Xu X, Dong J, Brant JO, Zhou W, Guan J, Jiang W, Li C. Discovery and Mechanism of 16-19F, a Novel Synthetic Lethal Inhibitor of the PRMT5*MTA Complex in MTAP-Deleted Cancer Cells. ACS Chem Biol. 2025 May 29. doi: 10.1021/acschembio.5c00160. Online ahead of print. PubMed PMID: 40440106.

Torres S, Jain V, Stribling D, Gay LA, Naeem M, Baddoo M, Flemington EK, Tibbetts SA, Renne R. A viral circular RNA in Kaposi’s sarcoma-associated herpesvirus modulates viral and host gene expression during latent and lytic replication. Explor Target Antitumor Ther. 2025 May 29;6:1002320. doi: 10.37349/etat.2025.1002320. eCollection 2025. PubMed PMID: 40452889; PubMed Central PMCID: PMC12123221.

Xu H, Hutchinson TE, Koganti S, Rousseau BA, Xia D, McIntosh MT, Bhaduri-McIntosh S. Leveraging the interconnected unfolded protein response and NLRP3 inflammasome pathways to reactivate Epstein-Barr virus in diffuse large B-cell lymphomas. NAR Cancer. 2025 May 5;7(2):zcaf017. doi: 10.1093/narcan/zcaf017. eCollection 2025 Jun. PubMed PMID: 40330549; PubMed Central PMCID: PMC12051106.

Wang Q, Pan Y, Zhou M, Tang Z, Wang Y, Wang G, Song Q. scDrugMap: Benchmarking Large Foundation Models for Drug Response Prediction. ArXiv [Preprint]. 2025 May 8:arXiv:2505.05612v1. PubMed PMID: 40386575; PubMed Central PMCID: PMC12083700.

Nagai R, Milam OL, Niwa T, Howell WJ, Best JA, Yoshida H, Freeburg CD, Koomen JM, Fujii K. Ribosomal expansion segment contributes to translation fidelity via N-terminal processing of ribosomal proteins. Nucleic Acids Res. 2025 May 22;53(10):gkaf448. doi: 10.1093/nar/gkaf448. PubMed PMID: 40433980; PubMed Central PMCID: PMC12117404.

Chen W, Zhang P, Tran TN, Xiao Y, Li S, Shah VV, Cheng H, Brannan KW, Youker K, Lai L, Fang L, Yang Y, Le NT, Abe JI, Chen SH, Ma Q, Chen K, Song Q, Cooke JP, Wang G. A visual-omics foundation model to bridge histopathology with spatial transcriptomics. Nat Methods. 2025 May 29. doi: 10.1038/s41592-025-02707-1. Online ahead of print. PubMed PMID: 40442373.

Kasap C, Izgutdina A, Patino-Escobar B, Kang AS, Chilakapati N, Akagi N, Manoj AM, Johnson H, Rashid T, Werner J, Barpanda A, Geng H, Lin YT, Rampersaud S, Gil-Alos D, Sobh A, Dupere-Richer D, Aleman A, Wicaksono G, Kelii KMK, Dalal R, Ramos E, Vijayanarayanan A, Lakhani K, Salangsang F, Phojanakong P, Camara Serrano JA, Zakraoui O, Tariq I, Chari A, Chung A, Kumar AD, Martin T, Wolf JL, Wong S, Steri V, Shanmugam M, Boise LH, Kortemme T, Parekh S, Stieglitz E, Licht JD, Karlon W, Barwick BG, Wiita A. Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells. Blood. 2025 May 13:blood.2024025536. doi: 10.1182/blood.2024025536. Online ahead of print. PubMed PMID: 40359480.

Rana AB, Horton TM, Thakur VS, Wang D, Thakur V, Dalzell M, Freitas JT, Gannamedi DP, Ogobuiro I, Bedogni B, Gultekin SH, Garrett TJ, Villarino AV, Lu J, Lombard DB, Shah AH, Welford SM. Polyamine acetylation mediates crosstalk between cancer cells and myeloid cells to promote mesenchymal/plurimetabolic states in glioblastoma. Neuro Oncol. 2025 May 27:noaf128. doi: 10.1093/neuonc/noaf128. Online ahead of print. PubMed PMID: 40424600.