MARCH 2025 PUBLICATIONS » Connection Newsletter » UF Health Cancer Center

Cancer Control AND Population Sciences

Cancer Targeting AND Therapeutics

Immuno-Oncology AND Microbiome

Mechanisms of Oncogenesis

Cancer Control and Population Sciences

Paragji A, Shastri V, Nasri E, Ligon JA, Elliott LA, Castillo-Caro P, Lamba JK, Sayour EJ, Seligson ND. Revisiting CDKN2A dysregulation in Ewing sarcoma. Mol Oncol. 2025 Mar 13. doi: 10.1002/1878-0261.70008. Online ahead of print. PubMed PMID: 40080912.

Festa BM, Schaefer N, Reschly W, Mendenhall WM, Conrad D, Hanubal K, Shama M, Dirain CO, Hughley B, Danan D, Dziegielewski PT. P16/HPV-negative oropharyngeal squamous cell carcinoma survival: Comparing primary surgery to primary chemoradiotherapy. A systematic review and meta-analysis. Eur J Surg Oncol. 2025 Mar 3;51(7):109739. doi: 10.1016/j.ejso.2025.109739. Online ahead of print. PubMed PMID: 40101682.

Griffin I, Pasini R, Mehrad B, Al-Ani M, Mohammed TL, Gomez Manjarres D, Patel D, Altmayer S, Marchiori E, Hochhegger B. The evolving role of MRI in pulmonary sarcoidosis: Comparative analysis with PFTs and progression markers. Sarcoidosis Vasc Diffuse Lung Dis. 2025 Mar 18;42(1):15304. doi: 10.36141/svdld.v42i1.15304. PubMed PMID: 40100106.

Clarke HA, Hawkinson TR, Shedlock CJ, Medina T, Ribas RA, Wu L, Liu Z, Ma X, Xia Y, Huang Y, He X, Chang JE, Young LEA, Juras JA, Buoncristiani MD, James AN, Rushin A, Merritt ME, Mestas A, Lamb JF, Manauis EC, Austin GL, Chen L, Singh PK, Bian J, Vander Kooi CW, Evers BM, Brainson CF, Allison DB, Gentry MS, Sun RC. Glycogen drives tumour initiation and progression in lung adenocarcinoma. Nat Metab. 2025 Mar 11. doi: 10.1038/s42255-025-01243-8. Online ahead of print. PubMed PMID: 40069440.

Smith LA, Cahill JA, Lee JH, Graim K. Equitable machine learning counteracts ancestral bias in precision medicine. Nat Commun. 2025 Mar 10;16(1):2144. doi: 10.1038/s41467-025-57216-8. PubMed PMID: 40064867; PubMed Central PMCID: PMC11894161.

Wisdom AJ, Yeap BY, Michalski JM, Horick NK, Zietman AL, Christodouleas JP, Kamran SC, Parikh RR, Vapiwala N, Mihalcik S, Miyamoto DT, Zeng J, Gay HA, Pisansky TM, Mishra MV, Spratt DE, Mendenhall NP, Soffen EM, Bekelman JE, Efstathiou JA. Setting the Stage: Feasibility and Baseline Characteristics in the PARTIQoL Trial Comparing Proton Therapy Versus Intensity Modulated Radiation Therapy for Localized Prostate Cancer. Int J Radiat Oncol Biol Phys. 2025 Mar 1;121(3):741-751. doi: 10.1016/j.ijrobp.2024.09.043. Epub 2024 Sep 30. PubMed PMID: 39357788.

Wei YJ, Schmidt S, Fillingim RB, Brock G, Schmidt S, Winterstein AG. Unrelieved pain and risk of opioid use disorder or overdose in older adults prescribed opioids. Pain. 2025 Mar 18. doi: 10.1097/j.pain.0000000000003589. Online ahead of print. PubMed PMID: 40096068.

Mielke MM, Fielding RA, Atkinson EJ, Aversa Z, Schafer MJ, Cummings SR, Pahor M, Leeuwenburgh C, LeBrasseur NK. Biomarkers of cellular senescence predict risk of mild cognitive impairment: Results from the lifestyle interventions for elders (LIFE) study. J Nutr Health Aging. 2025 Mar 7;29(5):100529. doi: 10.1016/j.jnha.2025.100529. Online ahead of print. PubMed PMID: 40056496.

Cabezas E, Toro-Tobon D, Johnson T, Alvarez M, Azadi JR, Gonzalez-Velasquez C, Ospina NS, Ponce OJ, Branda ME, Brito JP. ChatGPT-4’s Accuracy in Estimating Thyroid Nodule Features and Cancer Risk from Ultrasound Images. Endocr Pract. 2025 Mar 24:S1530-891X(25)00093-X. doi: 10.1016/j.eprac.2025.03.008. Online ahead of print. PubMed PMID: 40139461.

Shah KD, Yeap BY, Lee H, Soetan ZO, Moteabbed M, Muise S, Cowan J, Remillard K, Silvia B, Mendenhall NP, Soffen E, Mishra MV, Kamran SC, Miyamoto DT, Paganetti H, Efstathiou JA, Chamseddine I. Predictive Model of Acute Rectal Toxicity in Prostate Cancer Treated With Radiotherapy. JCO Clin Cancer Inform. 2025 Mar;9:e2400252. doi: 10.1200/CCI-24-00252. Epub 2025 Mar 19. PubMed PMID: 40106736; PubMed Central PMCID: PMC11938327.

Klitgaard R, Fjaera LF, Stokkevag CH, Johnson P, Artz M, Mendenhall NP, Bryant C, Muren LP. Modelling of a double-scattering proton therapy nozzle using the FLUKA Monte Carlo code and analysis of linear energy transfer in patients treated for prostate cancer. J Appl Clin Med Phys. 2025 Mar 19:e70032. doi: 10.1002/acm2.70032. Online ahead of print. PubMed PMID: 40105033.

Riner AN, Velazquez-Villarreal EI, Rajpara S, Qian J, Jin Y, Loza D, Akki A, Herremans KM, Raj R, Williams TM, Merchant N, George TJ, Hughes SJ, Stern MC, Reams R, Redda K, Wilkie DJ, Odedina FT, Chamala S, Han B, Agyare E, Craig DW, Carpten JD, Trevino JG. Somatic Genomic Profiling of Pancreatic Ductal Adenocarcinomas From a Diverse Cohort of Patients. Pancreas. 2025 Mar 1;54(3):e171-e178. doi: 10.1097/MPA.0000000000002408. PubMed PMID: 39999309.

G Bouchard E, Prince MA, McCarty C, Collins RL, Sahler OJZ, Vincent PC, Patel H, LaValley SA, Krenz T, Devonish JA, Kelly KM. Socioeconomic inequalities in social support: Examining differences in social support network satisfaction and composition among pediatric cancer caregivers. J Psychosoc Oncol. 2025 Mar 27:1-14. doi: 10.1080/07347332.2025.2483397. Online ahead of print. PubMed PMID: 40146076.

Cancer Targeting and Therapeutics

Chang MC, Malut VR, Mahar R, Rushin A, McLeod MA, Pierre GL, Malut IR, Staklinski SJ, Glanz ME, Ragavan M, Sharma G, Madheswaran M, Badar A, Rao AD, Law BK, Kilberg MS, Collins JHP, Kodibagkar VD, Bankson JA, DeBerardinis RJ, Merritt ME. Assessing cancer therapeutic efficacy in vivo using [2H7]glucose deuterium metabolic imaging. Sci Adv. 2025 Mar 28;11(13):eadr0568. doi: 10.1126/sciadv.adr0568. Epub 2025 Mar 26. PubMed PMID: 40138413; PubMed Central PMCID: PMC11939044.

Le MN, Chen D, Smith KA, Tran DD, Fan ZH. Microfluidic isolation and release of live disseminated breast tumor cells in bone marrow. PLoS One. 2025 Mar 12;20(3):e0319392. doi: 10.1371/journal.pone.0319392. eCollection 2025. PubMed PMID: 40073025; PubMed Central PMCID: PMC11902295.

Tong F, Zhou W, Janiszewska M, Seath CP. Multiprobe Photoproximity Labeling of the EGFR Interactome in Glioblastoma Using Red-Light. J Am Chem Soc. 2025 Mar 19;147(11):9316-9327. doi: 10.1021/jacs.4c15537. Epub 2025 Mar 7. PubMed PMID: 40052329.

Disney MD. The Druggable Transcriptome Project: From Chemical Probes to Precision Medicines. Biochemistry. 2025 Mar 25. doi: 10.1021/acs.biochem.5c00006. Online ahead of print. PubMed PMID: 40131857.

Yang X, Wang J, Springer NA, Zanon PRA, Jia Y, Su X, Disney MD. Mapping small molecule-RNA binding sites via Chem-CLIP synergized with capillary electrophoresis and nanopore sequencing. Nucleic Acids Res. 2025 Mar 20;53(6):gkaf231. doi: 10.1093/nar/gkaf231. PubMed PMID: 40156856.

Kundu S, Guo J, Islam MS, Rohokale R, Jaiswal M, Guo Z. A New Strategy to Functionalize Exosomes via Enzymatic Engineering of Surface Glycans and its Application to Profile Exosomal Glycans and Endocytosis. Adv Sci (Weinh). 2025 Mar 19:e2415942. doi: 10.1002/advs.202415942. Online ahead of print. PubMed PMID: 40106306.

Liu D, Ton PM, Zong D, Zarrinpar A, Ding Y. Expression of Fluorescence Reporters and Natural Products in Native Gut Escherichia coli. ACS Synth Biol. 2025 Mar 26. doi: 10.1021/acssynbio.4c00835. Online ahead of print. PubMed PMID: 40138712.

Chisolm SJ, Guo E, Subramaniam V, Schulze KD, Angelini TE. Elastic modulus versus cell packing density in MDCK epithelial monolayers. J Biomech. 2025 Mar 25;184:112648. doi: 10.1016/j.jbiomech.2025.112648. Online ahead of print. PubMed PMID: 40157056.

Ma X, Shedlock CJ, Medina T, Ribas RA, Clarke HA, Hawkinson TR, Dande PK, Golamari HKR, Wu L, Ziani BE, Burke SN, Merritt ME, Vander Kooi CW, Gentry MS, Yadav NN, Chen L, Sun RC. AI-driven framework to map the brain metabolome in three dimensions. Nat Metab. 2025 Mar 18. doi: 10.1038/s42255-025-01242-9. Online ahead of print. PubMed PMID: 40102678.

Berko ER, Naranjo A, Daniels AA, McNulty SN, Krytska K, Druley T, Zelley K, Koneru B, Chen L, Polkosnik G, Irwin MS, Bagatell R, Maris JM, Reynolds CP, DuBois SG, Park JR, Mosse YP. Frequency and Clinical Significance of Clonal and Subclonal Driver Mutations in High-Risk Neuroblastoma at Diagnosis: A Children’s Oncology Group Study. J Clin Oncol. 2025 Mar 4:JCO2402407. doi: 10.1200/JCO-24-02407. Online ahead of print. PubMed PMID: 40036726.

Wang Z, Skwarska A, Poigaialwar G, Chaudhry S, Rodriguez-Meira A, Sui P, Olivier E, Jia Y, Gupta V, Fiskus W, Ramage CL, Zheng G, Schurer A, Gritsman K, Papapetrou EP, Bhalla KN, Zhou D, Mead AJ, Rampal RK, Tyner JW, Abbas HA, Pemmaraju N, Tatarata QZ, Konopleva MY. Efficacy of a Novel BCL-xL Degrader, DT2216, in Preclinical Models of JAK2-mutated Post-MPN AML. Blood. 2025 Mar 31:blood.2024027117. doi: 10.1182/blood.2024027117. Online ahead of print. PubMed PMID: 40163809.

Alvarez J, Zambare W, George M, Garcia R, Gallagher P, Kitchens C, Bercz A, Kim MJ, Romesser PB, Cercek A, Garcia-Aguilar J, Sanoff H, George TJ, Hong TS, Yothers G, Philip PA, Al Baghdadi T, Alese OB, Shergill A, O’Reilly EM, Meyerhardt JA, Horvat N, Dasari A, Hall WA, Shi Q, Schrag D, Smith JJ. Utilizing Patient Input in Rectal Cancer Trial Design. J Natl Cancer Inst. 2025 Mar 19:djaf074. doi: 10.1093/jnci/djaf074. Online ahead of print. PubMed PMID: 40108482.

Yadav GP, Annamalai M, Hagan DW, Cui L, Mathews C, Jiang QX. Molecular requirements of chromogranin B for the long-sought anion shunter of regulated secretion. Int J Biol Macromol. 2025 Mar 17:142180. doi: 10.1016/j.ijbiomac.2025.142180. Online ahead of print. PubMed PMID: 40107558.

Cohen R, Raeisi M, Chibaudel B, Yothers G, Goldberg RM, Bachet JB, Wolmark N, Yoshino T, Schmoll HJ, Haller DG, Kerr R, Lonardi S, George TJ, Shacham-Shmueli E, Shi Q, Andre T, de Gramont A. Impact of tumor and node stages on the efficacy of adjuvant oxaliplatin-based chemotherapy in stage III colon cancer patients: an ACCENT pooled analysis. ESMO Open. 2025 Mar;10(3):104481. doi: 10.1016/j.esmoop.2025.104481. Epub 2025 Mar 4. PubMed PMID: 40043353; PubMed Central PMCID: PMC11928968.

Rajdev L, King GG, Lieu CH, Cohen SA, Pant S, Uboha NV, Deming D, Malla M, Kasi A, Klute K, Spencer KR, Dasari A, Morris VK, Botta G, Lowy AM, O’Hara MH, Eads J, King D, Shah MA, Hong TS, Parikh A, Klempner SJ, Jabbour SK, Chawla A, Molena D, George TJ, Gibson MK, Allegra C, Goodman K, Eng C, Philip PA. Incorporating Circulating Tumor DNA Testing Into Clinical Trials: A Position Paper by the National Cancer Institute GI Oncology Circulating Tumor DNA Working Group. JCO Precis Oncol. 2025 Mar;9:e2400489. doi: 10.1200/PO-24-00489. Epub 2025 Mar 6. PubMed PMID: 40048671; PubMed Central PMCID: PMC11893001.

Rao KN, Sreeram MP, de Bree R, Mendenhall WM, Strojan P, Stenman G, Makitie A, Nadal A, Rodrigo JP, Ng SP, Corry J, Rinaldo A, Eisbruch A, Ferlito A. The Oncological Outcome of Postoperative Radiotherapy in Patients with Node-Negative Early-Stage (T1/T2/N0) Oral Squamous Cell Carcinoma and Perineural Invasion: A Meta-Analysis. Cancers (Basel). 2025 Mar 3;17(5):862. doi: 10.3390/cancers17050862. PubMed PMID: 40075709; PubMed Central PMCID: PMC11899070.

Aye JM, Xue W, Gao Z, Ladra M, Indelicato DJ, Sheyn A, Dasgupta R, Arnold MA, Shenoy A, Linardic CM, Venkatramani R. Nonorbital, Nonparameningeal Head and Neck Rhabdomyosarcoma: A Report From the Children’s Oncology Group. Pediatr Blood Cancer. 2025 Mar 19:e31673. doi: 10.1002/pbc.31673. Online ahead of print. PubMed PMID: 40108481.

Bourgeois AD, Skinner OT, Karnia JJ, Smith AC, Kim DY, Gallastegui A, Griffin MA, O’Neill M, Wustefeld-Janssens BG, Fontes GS, Selmic LE, Traverson M, de M Souza CH, Bertran J, Thomsen B, Vinayak A, Mickelson MA. Contrast-Enhanced Computed Tomography for Identification of Potential Malignancy in Canine Colorectal Mesenchymal Tumours. Vet Comp Oncol. 2025 Mar 8. doi: 10.1111/vco.13047. Online ahead of print. PubMed PMID: 40056897.

Kass JD, Arpey NC, Conway DJ, Gibbs CP, Scarborough MT, Spiguel AR. Orthopaedic Oncologic Consultation Using Asynchronous Telemedicine: Expedited Triage and Reduced Clinic Visits. J Am Acad Orthop Surg Glob Res Rev. 2025 Mar 14;9(3):e25.00028. doi: 10.5435/JAAOSGlobal-D-25-00028. eCollection 2025 Mar 1. PubMed PMID: 40096577; PubMed Central PMCID: PMC11913409.

Wong EJ, McDonald CM, Thomas E, Zarrinpar A, Lee L, Kim KM, Beaver TM, Al-Bahou R, Al JG, Calhoon JH, Hui DS. Outcomes of Coronary Artery Bypass Grafting for Asymptomatic Patients Referred for Renal Transplant. Clin Transplant. 2025 Mar;39(3):e70128. doi: 10.1111/ctr.70128. PubMed PMID: 40038064.

Solari FP, Case JB, Grosso FRV, Maxwell EA, Williams RW, Ham K, Cabrera R. Laparoscopic ultrasonography identifies more liver lesions in dogs compared to transabdominal ultrasonography. Am J Vet Res. 2025 Mar 21:1-7. doi: 10.2460/ajvr.25.01.0031. Online ahead of print. PubMed PMID: 40118025.

Nelson S, Gaza J, Ajayebi S, Masse R, Pho R, Scutero C, Martinusen S, Long L, Menezes A, Perez A, Denard C. PERRC: Protease Engineering with Reactant Residence Time Control. bioRxiv [Preprint]. 2025 Mar 4:2025.03.02.641063. doi: 10.1101/2025.03.02.641063. PubMed PMID: 40093119; PubMed Central PMCID: PMC11908129.

Immuno-Oncology and Microbiome

Thakur BK, Malaise Y, Choudhury SR, Neustaeter A, Turpin W, Streutker C, Copeland J, Wong EOY, Navarre WW, Guttman DS, Jobin C, Croitoru K, Martin A. Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal cancer. Nat Microbiol. 2025 Mar 3. doi: 10.1038/s41564-025-01938-4. Online ahead of print. PubMed PMID: 40033140.

Engleberg AI, Yang YT, Schall PZ, Takada M, Thaiwong-Nebelung T, Evans JM, Ostrander EA, Yuzbasiyan-Gurkan V. Transcriptome Analysis of Canine Histiocytic Sarcoma Tumors and Cell Lines Reveals Multiple Targets for Therapy. Cancers (Basel). 2025 Mar 12;17(6):954. doi: 10.3390/cancers17060954. PubMed PMID: 40149290; PubMed Central PMCID: PMC11940154.

Zhao S, Agyare E, Zhu X, Trevino J, Rogers S, Velazquez-Villarreal E, Brant J, Eliahoo P, Barajas J, Hoang BX, Han B. ECM Stiffness-Induced Redox Signaling Enhances Stearoyl Gemcitabine Efficacy in Pancreatic Cancer. Cancers (Basel). 2025 Mar 3;17(5):870. doi: 10.3390/cancers17050870. PubMed PMID: 40075719; PubMed Central PMCID: PMC11899364.

Mechanisms of Oncogenesis

Zhang DD. Thirty years of NRF2: advances and therapeutic challenges. Nat Rev Drug Discov. 2025 Mar 4. doi: 10.1038/s41573-025-01145-0. Online ahead of print. PubMed PMID: 40038406.

Smith LA, Cahill JA, Lee JH, Graim K. Equitable machine learning counteracts ancestral bias in precision medicine. Nat Commun. 2025 Mar 10;16(1):2144. doi: 10.1038/s41467-025-57216-8. PubMed PMID: 40064867; PubMed Central PMCID: PMC11894161.

Nelson S, Gaza J, Ajayebi S, Masse R, Pho R, Scutero C, Martinusen S, Long L, Menezes A, Perez A, Denard C. PERRC: Protease Engineering with Reactant Residence Time Control. bioRxiv [Preprint]. 2025 Mar 4:2025.03.02.641063. doi: 10.1101/2025.03.02.641063. PubMed PMID: 40093119; PubMed Central PMCID: PMC11908129.

Argani P, Wangsiricharoen S, Tretiakova M, Liu YJ, Falzarano SM, Collins K, Brimo F, Gross JM, Baraban E, Matoso A, Wakeman K, Corless C, Neff T, Smith BF, Abdel Satir A, Agaimy A, Antonescu CR, Charville GW, Sangoi AR. MEIS1::NCOA1 Primitive Spindle Cell Sarcoma of the Kidney: Report of 7 Cases of a Distinctive Clinicopathologic Entity. Am J Surg Pathol. 2025 Mar 31. doi: 10.1097/PAS.0000000000002386. Online ahead of print. PubMed PMID: 40160183.

Zeng M, Zhang X, Li Y, Lu C, Yin R, Guo F, Li M. RNALoc-LM: RNA subcellular localization prediction using pre-trained RNA language model. Bioinformatics. 2025 Mar 22:btaf127. doi: 10.1093/bioinformatics/btaf127. Online ahead of print. PubMed PMID: 40119908.