JUNE 2024 PUBLICATIONS » Connection Newsletter » UF Health Cancer Center

Cancer Control AND Population Sciences

Cancer Targeting AND Therapeutics

Immuno-Oncology AND Microbiome

Mechanisms of Oncogenesis

Cancer Control and Population Sciences

Yaghjyan L, Heng YJ, Baker GM, Murthy D, Mahoney MB, Rosner B, Tamimi RM. Associations of stem cell markers CD44, CD24 and ALDH1A1 with mammographic breast density in women with benign breast biopsies. Br J Cancer. 2024 Jun 7. doi: 10.1038/s41416-024-02743-2. Online ahead of print. PubMed PMID: 38849477.

Brisson RJ, Indelicato DJ, Bradley JA, Aldana PR, Klawinski D, Cassidy V, Morris CG, Mailhot Vega RB. Long-term outcomes following proton therapy for non-metastatic central nervous system germinoma in children and adolescents. Radiother Oncol. 2024 Jun 8:110371. doi: 10.1016/j.radonc.2024.110371. Online ahead of print. PubMed PMID: 38857699.

Singh Ospina N, Diaz-Thomas A, McDonnell ME, Demay MB, Pittas AG, York E, Corrigan MD, Lash RW, Brito JP, Murad MH, McCartney CR. Navigating Complexities: Vitamin D, Skin Pigmentation, and Race. J Clin Endocrinol Metab. 2024 Jun 3:dgae314. doi: 10.1210/clinem/dgae314. Online ahead of print. PubMed PMID: 38828960.

Wang R, Lukose K, Ensz OS, Revere L, Hammarlund N. Emergency department visit frequency and health care costs following implementation of an integrated practice unit for frequent utilizers. Acad Emerg Med. 2024 Jun 26. doi: 10.1111/acem.14973. Online ahead of print. PubMed PMID: 38924643.

Nguyen T, Ordulu Z, Shrestha S, Patel U, Crispen PL, Brown L, Falzarano SM, Ghayee HK, Perdomo Rodriguez JP. Case report: A novel somatic SDHB variant in a patient with bladder paraganglioma. Front Endocrinol (Lausanne). 2024 Jun 7;15:1386285. doi: 10.3389/fendo.2024.1386285. eCollection 2024. PubMed PMID: 38911036; PubMed Central PMCID: PMC11190172.

Fullwood D, Fallon E, Pressey S, Bolajoko O, Young ME, Ruddy KJ, Wilkie DJ, Odedina FT. Voices of Black men: reflecting on prostate cancer survivorship care plans. J Cancer Surviv. 2024 Jun 24. doi: 10.1007/s11764-024-01624-0. Online ahead of print. PubMed PMID: 38914833.

Othman MO, Forsmark C, Yadav D, Singh VK, Lara LF, Park W, Zhang Z, Yu J, Kort JJ. Development of clinical screening tool for exocrine pancreatic insufficiency in patients with definite chronic pancreatitis. Pancreatology. 2024 Jun;24(4):545-552. doi: 10.1016/j.pan.2024.04.003. Epub 2024 Apr 16. PubMed PMID: 38693039.

Aloufi A, Aubee J, Vargas KM, Apprey V, Thompson K, Copeland R, Kanaan Y, Ricks-Santi L, Brim H, Abbas M. Vitamin D receptor polymorphisms and associated miRNAs in the development of breast cancer in African American women. Gene. 2024 Jun 28:148695. doi: 10.1016/j.gene.2024.148695. Online ahead of print. PubMed PMID: 38945313.

Varma JK, Zang C, Carton TW, Block JP, Khullar DJ, Zhang Y, Weiner MG, Rothman RL, Schenck EJ, Xu Z, Lyman K, Bian J, Xu J, Shenkman EA, Maughan C, Castro-Baucom L, O’Brien L, Wang F, Kaushal R; RECOVER Consortium. Excess burden of respiratory and abdominal conditions following COVID-19 infections during the ancestral and Delta variant periods in the United States: An EHR-based cohort study from the RECOVER program. PLoS One. 2024 Jun 6;19(6):e0282451. doi: 10.1371/journal.pone.0282451. eCollection 2024. PubMed PMID: 38843159; PubMed Central PMCID: PMC11156291.

French R, Bradford HM, Cousin L, Grunin L, Jones KF, Muchira J, Ferrara S. Nurses in health policy: Lessons learned from one cohort of the American Academy of Nursing Jonas Policy Scholars Program. Nurs Outlook. 2024 Jun 21;72(5):102175. doi: 10.1016/j.outlook.2024.102175. Online ahead of print. PubMed PMID: 38908294.

Gera K, Cline C, Al-Mansour Z, Medvec A, Lee JH, Galochkina Z, Hsu J, Hiemenz J, Farhadfar N, Dean EA, Wingard JR, Brown R. A phase ib clinical trial of oral ciprofloxacin and etoposide in subjects with resistant acute myeloid leukemia. Leuk Lymphoma. 2024 Jun 6:1-9. doi: 10.1080/10428194.2024.2361111. Online ahead of print. PubMed PMID: 38841781.

Loor-Torres R, Duran M, Toro-Tobon D, Chavez MM, Ponce O, Jacome CS, Torres DS, Perneth SA, Montori V, Golembiewski E, Osorio MB, Fan JW, Ospina NS, Wu Y, Brito JP. A Systematic Review of Natural Language Processing Methods and Applications in Thyroidology. Mayo Clin Proc Digit Health. 2024 Jun;2(2):270-279. doi: 10.1016/j.mcpdig.2024.03.007. Epub 2024 May 21. PubMed PMID: 38938930; PubMed Central PMCID: PMC11210322.

Al Hasan MM, Ghazimoghadam S, Tunlayadechanont P, Mostafiz MT, Gupta M, Roy A, Peters K, Hochhegger B, Mancuso A, Asadizanjani N, Forghani R. Automated Segmentation of Lymph Nodes on Neck CT Scans Using Deep Learning. J Imaging Inform Med. 2024 Jun 27. doi: 10.1007/s10278-024-01114-w. Online ahead of print. PubMed PMID: 38937342.

Nakkash R, Tleis M, Khalil J, Romani M, Salloum RG. A qualitative study on tobacco use during the COVID-19 pandemic in Lebanon: Waterpipe and cigarette smokers’ views, risk perceptions, and behaviors. Tob Prev Cessat. 2024 Jun 27;10. doi: 10.18332/tpc/189770. eCollection 2024. PubMed PMID: 38938265; PubMed Central PMCID: PMC11209738.

Cancer Targeting and Therapeutics

Gui C, Kalkreuter E, Lauterbach L, Yang D, Shen B. Enediyne natural product biosynthesis unified by a diiodotetrayne intermediate. Nat Chem Biol. 2024 Jun 3. doi: 10.1038/s41589-024-01636-y. Online ahead of print. PubMed PMID: 38831037.

Min CK, Nwachukwu JC, Hou Y, Russo RJ, Papa A, Min J, Peng R, Kim SH, Ziegler Y, Rangarajan ES, Izard T, Katzenellenbogen BS, Katzenellenbogen JA, Nettles KW. Asymmetric allostery in estrogen receptor-alpha homodimers drives responses to the ensemble of estrogens in the hormonal milieu. Proc Natl Acad Sci U S A. 2024 Jun 11;121(24):e2321344121. doi: 10.1073/pnas.2321344121. Epub 2024 Jun 3. PubMed PMID: 38830107; PubMed Central PMCID: PMC11181081.

Shi J, Barman SC, Cheng S, Zeng Y. Metal-organic framework-interfaced ELISA probe enables ultrasensitive detection of extracellular vesicle biomarkers. J Mater Chem B. 2024 Jun 10. doi: 10.1039/d4tb00585f. Online ahead of print. PubMed PMID: 38856318.

AlSaeed MJ, Ramdhan P, Malave JG, Eljilany I, Langaee T, McDonough CW, Seabra G, Li C, Cavallari LH. Assessing the Performance of In silico Tools and Molecular Dynamics Simulations for Predicting Pharmacogenetic Variant Impact. Clin Pharmacol Ther. 2024 Jun 18. doi: 10.1002/cpt.3348. Online ahead of print. PubMed PMID: 38894625.

Guest EM, Kairalla JA, Devidas M, Hibbitts E, Carroll AJ, Heerema NA, Kubaney HR, August MA, Ramesh S, Yoo B, Farooqi MS, Pauly MG, Wechsler DS, Miles RR, Reid JM, Kihei CD, Gore L, Raetz EA, Hunger SP, Loh ML, Brown PA. Azacitidine as epigenetic priming for chemotherapy is safe and well-tolerated in infants with newly diagnosed KMT2A-rearranged acute lymphoblastic leukemia: Children’s Oncology Group trial AALL15P1. Haematologica. 2024 Jun 13. doi: 10.3324/haematol.2024.285158. Online ahead of print. PubMed PMID: 38867582.

Christopher MW, Klug AC, Lee JH, Ericson AC, Feizbakhsh Bazargani S, Dinglasan RR, Prentice BM, Garrett TJ. Indole-3-pyruvate: Analysis and Control of Tautomerism and Reactivity. Anal Chem. 2024 Jun 25;96(25):10399-10407. doi: 10.1021/acs.analchem.4c01584. Epub 2024 Jun 10. PubMed PMID: 38858849.

Zingariello CD, Chen DH, Raskind WH, Slayton WB, Subramony S, Severance J, Feagle M, Rasmussen SA. Assessing Long-Term Neurologic Outcomes in SAMD9L-Related Ataxia-Pancytopenia Syndrome. Mov Disord Clin Pract. 2024 Jun;11(6):728-733. doi: 10.1002/mdc3.14038. Epub 2024 Apr 9. PubMed PMID: 38594844; PubMed Central PMCID: PMC11145150.

Vaezi A, Ashby T, Schweitzer M, Ghali P, Mirsaeidi M. Interstitial Lung Disease as an emerging contributor to mortality in patients with Inflammatory Bowel Disease: A population-based epidemiological study. Clin Transl Gastroenterol. 2024 Jun 1. doi: 10.14309/ctg.0000000000000720. Online ahead of print. PubMed PMID: 38822801.

Kashif R, Horn B, Milner J, Joyce M, Dalal M, Lee JJ, McNerney K, Cline J, Fort J, Castillo P, Galvez J, Alperstein W, Ligon J, Ziga E, Crawford D, Chellapandian D. The role of donor type and pre-transplant immunosuppression on outcomes of hematopoietic stem cell transplantation in children and young adults with severe aplastic anemia. Pediatr Transplant. 2024 Jun;28(4):e14784. doi: 10.1111/petr.14784. PubMed PMID: 38766976.

Applebaum M, Ramesh S, Dyer E, Pomaville M, Doytcheva K, Dolezal J, Kochanny S, Terhaar R, Mehrhoff C, Patel K, Brewer J, Kusswurm B, Naranjo A, Shimada H, Sokol E, Cohn S, George R, Pearson A. Artificial intelligence-based morphologic classification and molecular characterization of neuroblastic tumors from digital histopathology. Res Sq [Preprint]. 2024 Jun 4:rs.3.rs-4396782. doi: 10.21203/rs.3.rs-4396782/v1. PubMed PMID: 38883758; PubMed Central PMCID: PMC11177984.

Immuno-Oncology and Microbiome

Ligon JA, Cupit-Link MC, Yu C, Levine J, Foley T, Rotz S, Sharma A, Gomez-Lobo V, Shah NN. Pediatric Cancer Immunotherapy and Potential for Impact on Fertility: A Need for Evidence-Based Guidance. Transplant Cell Ther. 2024 Jun 10:S2666-6367(24)00463-9. doi: 10.1016/j.jtct.2024.06.006. Online ahead of print. PubMed PMID: 38866240.

Takacs GP, Garcia JS, Hodges CA, Kreiger CJ, Sherman A, Harrison JK. Glioma-derived M-CSF and IL-34 license M-MDSCs to suppress CD8+ T cells in a NOS-dependent manner. bioRxiv [Preprint]. 2024 Jun 6:2024.06.05.597474. doi: 10.1101/2024.06.05.597474. PubMed PMID: 38895268; PubMed Central PMCID: PMC11185662.

Aybar-Torres A, Saldarriaga LA, Pham AT, Emtiazjoo AM, Sharma AK, Bryant AJ, Jin L. The common TMEM173 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice. bioRxiv [Preprint]. 2024 Jun 17:2023.10.05.561109. doi: 10.1101/2023.10.05.561109. PubMed PMID: 37886547; PubMed Central PMCID: PMC10602033.

Azad N, Hu Z, Sahin I, Iyer R, Aranha O, Hochster H, Pathak P, Paulson AS, Kalyan A, Liao CY, Tran N, Kelley RK, Heestand G, Cosgrove D, El-Khoueiry A, Borad M, Gabrail NY, Majeed U, Du L, Kamath S, Shumway N, Shroff R, Goyal L, Rosales M, Javle M. COMPANION-002 A clinical trial of investigational drug CTX-009 plus paclitaxel vs paclitaxel in second line advanced BTC. Future Oncol. 2024 Jun 4:1-8. doi: 10.1080/14796694.2024.2351351. Online ahead of print. PubMed PMID: 38861293.

Cornetta K, Lin TY, Tao H, Huang J, Piskorowski J, Wilcox P, Xie D, Yao J, House K, Nance E, Duffy L. Product Enhanced Reverse Transcriptase for assessing replication competent virus in vectors retroviral vectors pseudotyped with GALV and VSV-G envelopes. J Virol Methods. 2024 Jun 20:114988. doi: 10.1016/j.jviromet.2024.114988. Online ahead of print. PubMed PMID: 38908550.

Mechanisms of Oncogenesis

Shekhar R, O’Grady T, Keil N, Feswick A, Amador DAM, Tibbetts SA, Flemington EK, Renne R. High-density resolution of the Kaposi’s sarcoma associated herpesvirus transcriptome identifies novel transcript isoforms generated by long-range transcription and alternative splicing. Nucleic Acids Res. 2024 Jun 26:gkae540. doi: 10.1093/nar/gkae540. Online ahead of print. PubMed PMID: 38922687.

Willman GH, Xu H, Zeigler TM, McIntosh MT, Bhaduri-McIntosh S. Polymerase theta is a synthetic lethal target for killing Epstein-Barr virus lymphomas. J Virol. 2024 Jun 11:e0057224. doi: 10.1128/jvi.00572-24. Online ahead of print. PubMed PMID: 38860782.

Bhaduri-McIntosh S, Rousseau BA. KAP1/TRIM28 – antiviral and proviral protagonist of herpesvirus biology. Trends Microbiol. 2024 Jun 12:S0966-842X(24)00138-0. doi: 10.1016/j.tim.2024.05.007. Online ahead of print. PubMed PMID: 38871562.

Anazia K, Koenekoop L, Ferre G, Petracco E, Gutierrez-de-Teran H, Eddy MT. Interaction Networks within Disease-Associated GalphaS Variants Characterized by an Integrative Biophysical Approach. J Biol Chem. 2024 Jun 24:107497. doi: 10.1016/j.jbc.2024.107497. Online ahead of print. PubMed PMID: 38925329.

Church C, Fay CX, Kriukov E, Liu H, Cannon A, Baldwin LA, Crossman DK, Korf B, Wallace MR, Gross AM, Widemann BC, Kesterson RA, Baranov P, Wallis D. snRNA-seq of human cutaneous neurofibromas before and after selumetinib treatment implicates role of altered Schwann cell states, inter-cellular signaling, and extracellular matrix in treatment response. Acta Neuropathol Commun. 2024 Jun 21;12(1):102. doi: 10.1186/s40478-024-01821-z. PubMed PMID: 38907342; PubMed Central PMCID: PMC11191180.