FEBRUARY 2025 PUBLICATIONS » Connection Newsletter » UF Health Cancer Center

Cancer Control AND Population Sciences

Cancer Targeting AND Therapeutics

Immuno-Oncology AND Microbiome

Mechanisms of Oncogenesis

Cancer Control and Population Sciences

Miller SC, Dar MH, Finnell SME, Fish DG, Cogle CR. Medicaid and the Promise for Cure. JAMA Pediatr. 2025 Feb 1;179(2):197-202. doi: 10.1001/jamapediatrics.2024.5100. PubMed PMID: 39804636.

Yang S, Lou X, Ahmed MM, Kimmel SE, Daily KC, George TJ, Pepine CJ, Bian J, Braithwaite D, Zhang D, Guo Y. Impact of Pre-Existing Frailty on Cardiotoxicity Among Breast Cancer Patients Receiving Adjuvant Therapy. JACC CardioOncol. 2025 Feb;7(2):110-121. doi: 10.1016/j.jaccao.2024.10.012. Epub 2025 Jan 7. PubMed PMID: 39967196; PubMed Central PMCID: PMC11866446.

Braithwaite D, Karanth S, Slatore CG, Yang JJ, Tammemagi M, Gould MK, Silvestri GA. Burden of Comorbid Conditions Among Individuals Screened for Lung Cancer. JAMA Health Forum. 2025 Feb 7;6(2):e245581. doi: 10.1001/jamahealthforum.2024.5581. PubMed PMID: 39982715; PubMed Central PMCID: PMC11846005.

Augustin EM, Indelicato DJ, Bradley JA, Fortune EC 4th, Dagan R, Morris CG, Bradfield SM, Vega RBM. Long-Term Outcomes Following Radiotherapy for Pediatric Salivary Gland Tumors. Pediatr Blood Cancer. 2025 Feb 13:e31571. doi: 10.1002/pbc.31571. Online ahead of print. PubMed PMID: 39948319.

Mroz EL, Amin T, Kittelson S, Koch MK, Crowe A, Bluck S, Hauser J, Handzo GF, Wilkie DJ, Bylund CL. Sharing “off-script”: A qualitative analysis of providers’ empathic self-disclosures during dignity therapy. Palliat Support Care. 2025 Feb 6;23:e57. doi: 10.1017/S1478951524002098. PubMed PMID: 39911002.

Balaguru L, Chow L, Mifsud M, Feng A, Richmon JD, Lobaina D, Old MO, Kakarala K, Conrad D, Dziegielewski P. Free Flap Enhanced Recovery Protocols in Head and Neck Surgery. Facial Plast Surg Clin North Am. 2025 Feb;33(1):1-19. doi: 10.1016/j.fsc.2024.07.003. Epub 2024 Sep 17. PubMed PMID: 39523030.

Ladna M, Madhok I, Bhat A, Ruiz N, Brown J, Wilson J, Jiang P, Taylor R, Radetic M, George J, Forsmark C. International Classification of Diseases, Tenth Revision Diagnosis Codes Are Overutilized in the Diagnosis of Chronic Pancreatitis. Pancreas. 2025 Feb 1;54(2):e97-e100. doi: 10.1097/MPA.0000000000002399. Epub 2024 Aug 12. PubMed PMID: 39928887.

Yu B, Ozdemir S, Dong Y, Shao W, Pan T, Shi K, Gong K. Robust whole-body PET image denoising using 3D diffusion models: evaluation across various scanners, tracers, and dose levels. Eur J Nucl Med Mol Imaging. 2025 Feb 6. doi: 10.1007/s00259-025-07122-4. Online ahead of print. PubMed PMID: 39912940.

Chellian R, Behnood-Rod A, Bruijnzeel AW. The role of glucocorticoid and nicotinic acetylcholine receptors in the reward-enhancing effects of nicotine in the ICSS procedure in male and female rats. Drug Alcohol Depend. 2025 Feb 1;267:112531. doi: 10.1016/j.drugalcdep.2024.112531. Epub 2024 Dec 20. PubMed PMID: 39752924.

Wei YJ, Winterstein AG, Schmidt S, Fillingim RB, Schmidt S, Daniels MJ, DeKosky ST. Prescription opioid use and cognitive function in older adults with chronic pain: A population-based longitudinal cohort study. Alzheimers Dement. 2025 Feb;21(2):e70002. doi: 10.1002/alz.70002. PubMed PMID: 39989238; PubMed Central PMCID: PMC11848163.

Nguyen L, Ajredini R, Guo S, Romano LEL, Tomas RF, Bell LR, Ranum PT, Zu T, Banez Coronel M, Kelley CP, Redding-Ochoa J, Nizamis E, Melloni A, Connors TR, Gaona A, Thangaraju K, Pletnikova O, Clark HB, Davidson BL, Yachnis AT, Golde TE, Lou X, Wang ET, Renton AE, Goate A, Valdmanis PN, Prokop S, Troncoso JC, Hyman BT, Ranum LPW. CASP8 intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer’s disease risk. Proc Natl Acad Sci U S A. 2025 Feb 18;122(7):e2416885122. doi: 10.1073/pnas.2416885122. Epub 2025 Feb 12. PubMed PMID: 39937857; PubMed Central PMCID: PMC11848317.

Short E, Huckstepp RTR, Alavian K, Amoaku WMK, Barber TM, van Beek EJR, Benbow E, Bhandari S, Bloom P, Cota C, Chazot P, Christopher G, Demaria M, Erusalimsky JD, Ferenbach DA, Foster T, Gazzard G, Glassock R, Jamal N, Kalaria R, Kanamarlapudi V, Khan AH, Krishna Y, Leeuwenburgh C, van der Linde I, Lorenzini A, Maier AB, Medina RJ, Miotto CL, Mukherjee A, Mukkanna K, Murray JT, Nirenberg A, Palmer DB, Pawelec G, Reddy V, Rosa AC, Rule AD, Shiels PG, Sheridan C, Tree J, Tsimpida D, Venables ZC, Wellington J, Calimport SRG, Bentley BL. International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus. Geroscience. 2025 Feb 21. doi: 10.1007/s11357-025-01509-9. Online ahead of print. No abstract available. PubMed PMID: 39982667.

Wei YJ, Winterstein AG, Schmidt S, Fillingim RB, Schmidt S, Daniels MJ, DeKosky ST, Young H, Cheng TD. Outcomes of Discontinuing Long-Term Opioid Therapy Among Older Cancer Survivors in Long-Term Care Settings. J Am Med Dir Assoc. 2025 Feb 24:105522. doi: 10.1016/j.jamda.2025.105522. Online ahead of print. PubMed PMID: 40015331.

Zhou T, Huang Y, Avanasi R, Brain RA, Prosperi M, Bian J. Content Hubs, Information Flows, And Reactions for Pesticide-Related Discussions On Twitter. Integr Environ Assess Manag. 2025 Feb 25:vjaf032. doi: 10.1093/inteam/vjaf032. Online ahead of print. PubMed PMID: 39999018.

Montalvo AD, Gong Y, Collins JM, Wang D. The Association Between Promoter Tandem Repeat Polymorphism (pVNTR) and CYP2C9 Gene Expression in Human Liver Samples. Genes (Basel). 2025 Feb 11;16(2):213. doi: 10.3390/genes16020213. PubMed PMID: 40004542; PubMed Central PMCID: PMC11855013.

Bellin MD, Andersen DK, Akshintala V, Born D, Coghill RC, Easler J, Fogel EL, Forsmark CE, Freeman AJ, Hughes SJ, Jensen A, Liran O, Martin L, Pandol SJ, Palermo TM, Papachristou GI, Park WG, Phillips AE, Schwarzenberg SJ, Singh VK, Toledo FGS, VanDalfsen J, Whitcomb DC, Wu B, Yadav D. Heterogeneity in Pancreatitis: Recognizing Heterogeneity and Its Role in the Management of Pancreatitis Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas. 2025 Feb 1;54(2):e114-e121. doi: 10.1097/MPA.0000000000002403. Epub 2024 Dec 11. PubMed PMID: 39661048.

Heath F, Ockerman K, Wiesemann GS, Safeek R, Heath M, Momeni A, Spiguel LR, Kovach S, Sorice-Virk S. Changes in Relationship Dynamics in Men and Women After Receiving the Diagnosis of Breast Versus Prostate Cancer: A Population-based Study. Plast Reconstr Surg Glob Open. 2025 Feb 21;13(2):e6494. doi: 10.1097/GOX.0000000000006494. eCollection 2025 Feb. PubMed PMID: 39989894; PubMed Central PMCID: PMC11845180.

Cancer Targeting and Therapeutics

Neyroud D, D’Lugos AC, Trevino EJ, Callaway CS, Lamm J, Laitano O, Poole B, Deyhle MR, Brantley J, Le L, Judge AR, Judge SM. Local Inflammation Precedes Diaphragm Wasting and Fibrotic Remodelling in a Mouse Model of Pancreatic Cancer. J Cachexia Sarcopenia Muscle. 2025 Feb;16(1):e13668. doi: 10.1002/jcsm.13668. PubMed PMID: 39810606; PubMed Central PMCID: PMC11733308.

Jang T, Kim GP, George TJ. Select updates from ASCO and ESMO 2024 for gastrointestinal cancer care. Oncologist. 2025 Feb 6;30(2):oyaf020. doi: 10.1093/oncolo/oyaf020. PubMed PMID: 39998903; PubMed Central PMCID: PMC11853594.

Ducharme JB, Carelock ME, Schonk MM, Al-Zaeed NM, Zhang W, Judge SM, Judge AR. Identification of a senescence-associated transcriptional program in skeletal muscle of cachectic pancreatic-tumor bearing mice. Am J Physiol Cell Physiol. 2025 Feb 24. doi: 10.1152/ajpcell.00816.2024. Online ahead of print. PubMed PMID: 39993009.

Taghavi A, Springer NA, Zanon PRA, Li Y, Li C, Childs-Disney JL, Disney MD. The evolution and application of RNA-focused small molecule libraries. RSC Chem Biol. 2025 Feb 13. doi: 10.1039/d4cb00272e. Online ahead of print. PubMed PMID: 39957993; PubMed Central PMCID: PMC11824871.

Shan G, Zhang Y, Tang Z, Wang G, Wu SS. Disease progression trajectory curves to estimate saved time in Alzheimer’s disease trials. Contemp Clin Trials. 2025 Feb 7;151:107814. doi: 10.1016/j.cct.2025.107814. Online ahead of print. PubMed PMID: 39923891.

MacTavish BS, Zhu D, Shang J, Shao Q, He Y, Yang ZJ, Kamenecka TM, Kojetin DJ. Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states. Nat Commun. 2025 Feb 28;16(1):2065. doi: 10.1038/s41467-025-57325-4. PubMed PMID: 40021712; PubMed Central PMCID: PMC11871303.

Vergote I, Copeland LJ, Van Gorp T, Laenen A, Scambia G, Thaker PH, Cibula D, Colombo N, Lea J, Gonzalez-Martin A, Korach J, Sehouli J, Monk BJ, Heinzelmann-Schwarz V, Berger R, Buscema J, Lau S, Madry R, Denys H, Pepin JT, Salutari V, Bagameri A, Ardizzoia A, Henry S, Cecere SC, Hruda M, Iglesias DA, Manso L, Shai A, O’Malley DM; ENGOT-ov50/GOG-3029/INNOVATE-3 Study Investigators. Tumor Treating Fields therapy in platinum-resistant ovarian cancer: Results of the ENGOT-ov50/GOG-3029/INNOVATE-3 pivotal phase 3 randomized study. Eur J Cancer. 2025 Feb 17;219:115306. doi: 10.1016/j.ejca.2025.115306. Online ahead of print. PubMed PMID: 40010134.

Javed MJ, Howard RM, Li H, Carrasco L, Dirain MLS, Su G, Cai G, Upchurch GR Jr, Jiang Z. GSDMD Deficiency Attenuates the Development of Ascending Aortic Dissections in a Novel Mouse Model. Arterioscler Thromb Vasc Biol. 2025 Feb 13. doi: 10.1161/ATVBAHA.124.321740. Online ahead of print. PubMed PMID: 39945067.

Zhu B, Pitts MG, Buoncristiani MD, Bryant LT, Lopez-Nunez O, Gurria JP, Shedlock C, Ribas R, Keohane S, Liu J, Wang C, Gentry MS, Shelman NR, Allison DB, Evers BM, Sun RC, Rellinger EJ. GDP-mannose 4,6-dehydratase is a key driver of MYCN-amplified neuroblastoma core fucosylation and tumorigenesis. Oncogene. 2025 Feb 16. doi: 10.1038/s41388-025-03297-0. Online ahead of print. PubMed PMID: 39956863.

Hall BT, Eken E, Cavallari LH, Duarte JD, Wiisanen KW, Cicali EJ, Nguyen KA. Implementing Pharmacogenomics Clinical Decision Support: A Comprehensive Tutorial on how to Integrate the Epic Genomics Module. Clin Pharmacol Ther. 2025 Feb 17. doi: 10.1002/cpt.3599. Online ahead of print. PubMed PMID: 39960348.

Jamouss KT, Damanakis AI, Cornwell AC, Jongepier M, Trujillo MA, Pfluger MJ, Kawalerski R, Maalouf A, Hirose K, Datta S, Sipes A, Pedro BA, Gudmundsson E, Assarzadegan N, Engle L, Scharpf RB, Kawamoto S, Thompson ED, Wood LD. Tumor immune microenvironment alterations associated with progression in human intraductal papillary mucinous neoplasms. J Pathol. 2025 Feb 25. doi: 10.1002/path.6402. Online ahead of print. PubMed PMID: 40001347.

Finn RS, Iyer R, Kalman RS, Parikh ND, Cabrera R, Babajanyan S, Kaseb AO. Tolerability and Effectiveness of Regorafenib Treatment in Patients with Unresectable Hepatocellular Carcinoma: Real-World Data from the United States. J Hepatocell Carcinoma. 2025 Feb 7;12:231-246. doi: 10.2147/JHC.S459983. eCollection 2025. PubMed PMID: 39935697; PubMed Central PMCID: PMC11812560.

Casper A, Indelicato DJ, Amdur RJ, De Leo AN. Radiotherapy Target Volume Definition for Myxopapillary Ependymoma of the Lumbosacral Spine Without Indication for Craniospinal Irradiation: The Question of Extending the Target Inferiorly to Include the Proximal Nerve Roots and Thecal Sac. Pract Radiat Oncol. 2025 Feb 3:S1879-8500(25)00014-1. doi: 10.1016/j.prro.2025.01.009. Online ahead of print. No abstract available. PubMed PMID: 39909145.

Doxsee K, Paddock I, Friedman WA, Li JG, De Leo A, Koch M, Bova FJ. A Comparison of Radiosurgical Planning Techniques for the Treatment of Trigeminal Neuralgia. Pract Radiat Oncol. 2025 Feb 27:S1879-8500(25)00010-4. doi: 10.1016/j.prro.2024.11.014. Online ahead of print. PubMed PMID: 40019414.

Oshins R, Huo Z, Greenberg Z, Clark V, Duarte S, Zhou H, West J, He M, Brantly M, Khodayari N. Plasma Extracellular Vesicle-derived MicroRNA Associated with Human Alpha-1 Antitrypsin Deficiency-mediated Liver Disease. J Clin Transl Hepatol. 2025 Feb 28;13(2):118-129. doi: 10.14218/JCTH.2024.00253. Epub 2024 Nov 19. PubMed PMID: 39917464; PubMed Central PMCID: PMC11797821.

Singal AG, Reddy KR, Colombo M, Morris HL, Mospan AR, Cabrera R, Kelley RK, Kilpatrick RD, Trevisani F, Farinati F, Giannini EG, Mehta N, Fried MW, Sangro B; DAA-PASS and ITA.LI.CA Investigators. DAA-PASS: A Prospective Evaluation of HCC Recurrence After Direct Acting Antiviral Therapy. J Viral Hepat. 2025 Feb;32(2):e14056. doi: 10.1111/jvh.14056. PubMed PMID: 39822115.

Abdallah N, Rathi N, Heller N, Wood A, Campbell R, Benidir T, Isensee F, Tejpaul R, Suk-Ouichai C, Palacios DA, You A, Viswanath S, Flannery B, Kaouk J, Haywood S, Krishnamurthi V, Papanikolopoulos N, Zabell J, Abouassaly R, Remer EM, Campbell S, Weight CJ. A Fully Automated Artificial Intelligence-Based Approach to Predict Renal Function After Radical or Partial Nephrectomy. Urology. 2025 Feb 4:S0090-4295(25)00121-9. doi: 10.1016/j.urology.2025.01.073. Online ahead of print. PubMed PMID: 39914676.

Yan M, Kollitz E, Sun SH, Hitchcock K, De Leo A, Schwarz A, Maloney L, Li J, Liu C, Yan G. Patient setup variation on Elekta Unity and its impact on adaptive planning. J Appl Clin Med Phys. 2025 Feb 12:e70016. doi: 10.1002/acm2.70016. Online ahead of print. PubMed PMID: 39940123.

Immuno-Oncology and Microbiome

Thomas RM. Microbial molecules, metabolites, and malignancy. Neoplasia. 2025 Feb;60:101128. doi: 10.1016/j.neo.2025.101128. Epub 2025 Jan 18. PubMed PMID: 39827500; PubMed Central PMCID: PMC11787689.

Doonan BP, Radwan FFY, Banik NL, Haque A. Using a Natural Triterpenoid to Unlock the Antitumor Effects of Autophagy in B-Cell Lymphoma. Biomedicines. 2025 Feb 12;13(2):445. doi: 10.3390/biomedicines13020445. PubMed PMID: 40002858; PubMed Central PMCID: PMC11853664.

Dougherty MW, Hoffmann RM, Hernandez MC, Airan Y, Gharaibeh RZ, Herzon SB, Yang Y, Jobin C. Genome-scale CRISPR/Cas9 screening reveals the role of PSMD4 in colibactin-mediated cell cycle arrest. mSphere. 2025 Feb 7:e0069224. doi: 10.1128/msphere.00692-24. Online ahead of print. PubMed PMID: 39918307.

Windermere SA, Shah S, Hey G, McGrath K, Rahman M. Applications of AI in Neurosurgery for Improving Outcomes through Diagnostics, Predictive Tools, and Resident Education. World Neurosurg. 2025 Feb 25:123809. doi: 10.1016/j.wneu.2025.123809. Online ahead of print. PubMed PMID: 40015674.

Ducharme JB, Carelock ME, Schonk MM, Al-Zaeed NM, Zhang W, Judge SM, Judge AR. Identification of a senescence-associated transcriptional program in skeletal muscle of cachectic pancreatic-tumor bearing mice. Am J Physiol Cell Physiol. 2025 Feb 24. doi: 10.1152/ajpcell.00816.2024. Online ahead of print. PubMed PMID: 39993009.

Das S, Nayak A, Siddharth S, Nayak D, Narayan S, Kundu CN. Retraction Note: TRAIL enhances quinacrine-mediated apoptosis in breast cancer cells through induction of autophagy via modulation of p21 and DR5 interactions. Cell Oncol (Dordr). 2025 Feb 12. doi: 10.1007/s13402-025-01045-w. Online ahead of print. No abstract available. PubMed PMID: 39962014.

Mechanisms of Oncogenesis

Yu F, Zheng S, Yu C, Gao S, Shen Z, Nar R, Liu Z, Huang S, Wu L, Gu T, Qian Z. KRAS Mutants Confer Platinum Resistance by Regulating ALKBH5 Post-translational Modifications in Lung Cancer. J Clin Invest. 2025 Feb 4:e185149. doi: 10.1172/JCI185149. Online ahead of print. PubMed PMID: 39960727.

Torma G, Dormo A, Fulop A, Tombacz D, Mizik M, Pretory AM, Lee S-C, Toth Z, Boldogkoi Z. Long-read transcriptomics of caviid gammaherpesvirus 1: compiling a comprehensive RNA atlas. mSystems. 2025 Feb 27:e0167824. doi: 10.1128/msystems.01678-24. Online ahead of print. PubMed PMID: 40013795.

de Souza C, Fidel J, Davis WC. Update on development of monoclonal antibodies for use in clinical flow cytometry and research in dogs. J Vet Diagn Invest. 2025 Feb 5:10406387251315530. doi: 10.1177/10406387251315530. Online ahead of print. PubMed PMID: 39910737; PubMed Central PMCID: PMC11803592.