Cancer Research News
CBD: The next weapon in the war against opioid addiction?
CBD, or cannabidiol, is everywhere, with word on the street saying that it can cure everything from a bad mood to cancer. However, most of these claims are not based on scientific evidence. Animal studies suggest that CBD might be beneficial for some health indications, such as pain, inflammation, arthritis and anxiety.
However, until recently, the only medical indication that CBD has been proven to treat in humans is seizures associated with pediatric epilepsy. Now, however, a recent study suggested that CBD curbed cravings in people with opioid dependence. This is one of the first double-blind controlled trials, the gold standard for drug research, to show benefit of using CBD outside epilepsy treatment. Thus, researchers can say with greater confidence that CBD may be helpful in fighting the war against opioid addiction. READ MORE
Dr. Robert Zlotecki discusses pancreatic cancer treatment strategies
Jeopardy! Game show host Alex Trebek recently announced that his pancreatic cancer is in partial remission. UF Health radiation oncologist Robert A. Zlotecki, M.D., discusses approaches to treating the disease.
NRG trial suggests total neoadjuvant therapy for locally advanced rectal cancer is safe
Results from the first experimental arm using veliparib as part of total neoadjuvant therapy (induction chemotherapy followed by chemoradiotherapy and surgery; TNT) in patients with locally advanced rectal adenocarcinoma on the NRG Oncology Phase II clinical trial NRG-GI002 were recently presented at the American Society of Clinical Oncology (ASCO) Annual Meeting. Results were reported on the primary endpoint of pathological regression via the neoadjuvant rectal cancer (NAR) score, a short-term clinical trial surrogate endpoint. READ MORE
From the Extension: Community wellness focus of new walking program
Walking has many benefits — physical exercise, weight loss, stress relief, better sleep and more positive mood. A new University of Florida walking program adds another benefit: comradery.
Let’s Walk Florida is a 12-week program where community members team up to start a lifelong walking habit, said LaToya O’Neal, assistant professor of family, youth and community sciences in the UF Institute of Food and Agricultural Sciences. READ MORE
y-Secretase Revisited—Could Selective Inhibitors Treat AD, Cancer Safely?
The side effects that emerged in AD trials have given γ-secretase inhibitors a bad rap. According to a paper published May 29 in Science Translational Medicine, it might be time to take a second look. Researchers led by Bart De Strooper and Jan Cools of KU Leuven, Belgium, reported that a small-molecule inhibitor that selectively targets presenilin-1 stifled the proliferation of leukemic T cells expressing a mutant form of the γ-secretase substrate Notch. The molecule—Merck’s MRK-560—prolonged survival in mice transplanted with human leukemic T cells. What’s more, it did so without any of the immune or gastrointestinal side effects caused by broad spectrum γ-secretase inhibitors. READ MORE